UČNI NAČRT PREDMETA/COURSE SYLLABUS

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1 Predmet Course title UČNI NAČRT PREDMETA/COURSE SYLLABUS Medikalizacija staranja Medicalization of aging Študijski program in stopnja Study programme and level Integrirana zdravstvena in socialna oskrba/2. stopnja Integrated Health and Social Care / 2 nd Cycle Študijska smer Study field Letnik Academic year Ni smeri študija 2. letnik 3. No study field 2 nd year 3 rd Semester Semester Vrsta predmeta/course type Univerzitetna koda predmeta/university course code modularni /module IZSO M1 UN 2 Predavanja Lectures Seminar Seminar Sem. vaje Tutorial Lab. vaje Laboratory Teren. vaje Field Samost. delo Individ. ECTS Nosilec predmeta/lecturer: doc. dr. Damijana Mojca Jurič Jeziki/ Languages: Predavanja/Lectures: slovenski/slovenian Vaje/Tutorial: slovenski/slovenian Pogoji za vključitev v delo oz. za opravljanje študijskih obveznosti: Vpis v drugi letnik študijskega programa. Prerequisites: Enrolment in the second year of study. Vsebina: Patofiziološke osnove staranja spremenjena sestava tkiv, spremenjeno delovanje organov - ledvic, jeter, srčnožilnega sistema, prebavil, endokrinega sistema in osrednjega živčevja Farmakodinamika zdravil v starosti spremembe na receptorjih za endogene mediatirje in zdravila, spremembe znotrajceličnih poti, encimov ter celičnih procesov, ki vplivajo na delovanje zdravil Farmakokinetika zdravil v starosti Content (Syllabus outline): Pathophysiological principles of aging altered compositions of tissues, altered function of organs kidneys, liver, cardiovascular system, gastrointestinal tract, endocrine system and central nervous system Pharmacodinamics of medications in aging changes in receptors for endogenous mediators and drugs, changes in intracellular signalling pathways, enzymes and cellular processes that influence the 1

2 spremembe v absorpciji, porazdelitvi, metabolizmu in izločanju zdravil Neželeni učinki zdravil posledice spremenjene farmakodinamike in farmakokinetike zdravil pri starostnikih Medsebojno delovanje zdravil in polifarmakoterapija povečana ali zmanjšana učinkovitost zdravil zaradi jemanja več zdravil hkrati Farmakoterapevtski izzivi kronične bolezni starostnikov Srčno-žilne bolezni Pljučne bolezni Endokrine bolezni Bolezni prebavil in prehrana Bolezni izločal Bolezni osrednjega živčevja Bolezni mišično-skeletnega sistema in vezivnih tkiv Anemija in zaščitna terapija Infekcije Bolečina Nevarnosti domače lekarne Vloga medicinske sestre pri jemanju zdravil starostnikov medicines effects Pharmacokinetics of medications in aging Changes in absorption, distribution, metabolism and elimination of drugs Adverse drug events consequences of changed drug pharmacodynamics and pharmacokinetics in aging Drug-drug interactions and polypharmacotherapy increased or decreased drug effects due to polipharmacotherapy Pharmacotherpaeutic issues - chronic diseases of elderly Cardiovascular disorders Respiratory disorders Endocrine disorders Gastrointestinal disorders and nutrition Renal/urologic disorders Central nervous system disorders Musculoskeletal and connective tissue disorders Anaemia and preventive therapy Infections Pain The risk of domestic pharmacy drugs The role of the nurse in medication of elderly Temeljna literatura in viri/readings: Temeljna literatura/basic literature Hutchison, L.C. in Sleeper, R.B. (2015). Fundamentals of geriatric pharmacotherapy: an evidenced-based approach, 2nd ed. Bethesda,: American Society of Health-System Pharmacists Atkinson, S. (2012). Geriatric Pharmacology: The Principles of Practice & Clinical Recommendations. Eau Claire, Wisconsin: PHC Publishing Group. Rang, H.P., Dale, M.M., Ritter, J.M. in Flower, R.J. (2015). Rang and Dale's Pharmacology, 8th ed. Edinburgh: Churchill, Livingstone Priporočljiva literatura/recommended literature Kladnik-Januš, B. (2006). Farmakologija. Maribor. Visoka zdravstvena šola. Karch, A.M., Sheader, E., Speake, T. in Griffiths, C. (2010). Focus on Nursing Pharmacology - UK Edition. London: Lippincott Williams & Wilkins. Izbrani članki iz zbornikov znanstvenih srečanj, izbrani članki iz domačih in tujih znanstvenih revij, izbrane internetne strani. 2

3 Cilji in kompetence: Učna enota prispeva predvsem k razvoju naslednjih splošnih in specifičnih kompetenc: povezovanje znanja interdisciplinarnih strokovnih področij, osvajanje novega znanja na področju holistične in k pacientu usmerjene zdravstvene in socialne oskrbe, prepoznavanje najpogostejših zdravstvenih in socialnih problemov, ki jih prinašajo kronične bolezni medpoklicno sodelovanje pri izvajanju integrirane in kontinuirane oskrbe na področju skrbi za zdravje, kakovost življenja in dobro počutje pacientov v instituciji ali na domu, kakovostno komuniciranje v negovalnem, zdravstvenem in multiprofesionalnem timu, razvoj in vzdrževanje dobrih medsebojnih odnosov med zaposlenimi, pacienti, njihovimi družinami, skupinami in skupnostjo. Objectives and competences: The learning unit mainly contributes to the development of the following general and specific competences: integration knowledge of interdisciplinary fields of expertise, the conquest of new knowledge in the field of holistic and patient-oriented health and social care, identification of the most common health and social problems posed by chronic diseases interprofessional collaboration in the implementation of an integrated and continuous care in the field of health care, quality of life and well-being of patients in an institution or at home quality communication in nursing, healthcare and multi-professional team, developing and maintaining good relations between employees, patients, their families, and community groups, Predvideni študijski rezultati: Študent/študentka: pozna patofiziološke spremembe, ki vplivajo na farmakokinetični in fakmakodinamski odziv na zdravila pri starostnikih razume prilagojene načine zdravljenja kroničnih bolezni starostnikov se usposobi za vrednotenje starostnikovega zdravstvenega stanja in za nadzor nad pravilnim jemanjem zdravil starostnikov na domu ali v instituciji Intended learning outcomes: Knowledge and understanding: Students: knows the pathophysiological changes that affect the pharmacokinetic and pharmacodinamic response to medications in the elderly understands customized methods of treatment chronic diseases of the elderly develops skills for evaluation of the elderly health monitoring and oversight of the proper administration of medications for older people at home or in an institution Metode poučevanja in učenja: predavanja z aktivno udeležbo študentov (razlaga, diskusija, vprašanja, primeri, reševanje problemov), vaje: priprava, predstavitev in uspešen zagovor projektne/raziskovalne naloge Learning and teaching methods: lectures with active student participation (explanation, discussion, questions, examples, problem solving); tutorial: preparation, presentation and a successful defence of a project paper 3

4 (reševanje problemov, študije primera, kritično presojanje, diskusija, refleksija izkušenj, vrednotenje, projektno delo, timsko delo). (problem solving, case studies with discussion, methods of critical thinking, reflection of experience, evaluating, project, team ). Načini ocenjevanja: Način: aktivna 100% udeležba na predavanjih in vajah ter priprava, predstavitev in zagovor raziskovalne naloge 100 % ocene; če študent ni 100 % udeležen na predavanjih in vajah: izpit 60 % ocene, priprava, predstavitev in zagovor raziskovalne naloge 40 % ocene. Ocenjevalna lestvica: ECTS. Delež (v %) Weight (in %) 100% ali 60 % 40 % Assessment: Types: 100% active participation in class discussions and preparation, presentation and defense of research papers - 100% of the grade; If the student is not 100% involved in class discussions: exam - 60% of the grade, preparation, presentation and defense of the research paper - 40% of the grade. Grading: ECTS. Reference nosilca/ Lecturer's references: Izvirni znanstveni članek/original scientific article 1. Jurič DM, Šuput D, Brvar M. Hyperbaric oxygen preserves neurotrophic activity of carbon monoxide-exposed astrocytes. Toxicology letters, 2016, 253, Jurič DM, Finderle Ž, Šuput D, Brvar M. The effectiveness of oxygen therapy in carbon monoxide poisoning is pressure- and time-dependent: a study on cultured astrocytes. Toxicology letters, 2015, 233, Mele T, Jurič DM. Metrifonate, like acetylcholine, up-regulates neurotrophic activity of cultured rat astrocytes. Pharmacological Reports, 2014, 66, Mele T, Jurič DM. Identification and pharmacological characterization of the histamine H[sub]3 receptor in cultured rat astrocytes. European Journal of Pharmacology, 2013, 720, Jurič DM, Mele T, Čarman-Kržan M. Involvement of histaminergic receptor mechanisms in the stimulation of NT-3 synthesis in astrocytes. Neuropharmacology, 2011, 60, Mele T, Čarman-Kržan M, Jurič DM. Regulatory role of monoamine neurotransmitters in astrocytic NT-3 synthesis. International Journal of Developmental Neuroscience, 2010, 28, Jurič DM, Lončar D, Čarman-Kržan M. Noradrenergic stimulation of BDNF synthesis in astrocytes: mediation via [alpha][sup]1- and ß[sup]1/ß[sup]2-adrenergic receptors. Neurochemistry International, 2008, 52, Jurič DM, Miklič Š, Čarman-Kržan M. Monoaminergic neuronal activity up-regulates BDNF synthesis in cultured neonatal rat astrocytes. Brain research, 2006, 1108, Miklič Š, Jurič DM, Čarman-Kržan M. Differences in the regulation of BDNF and 4

5 NGF synthesis in cultured neonatal rat astrocytes. International Journal of Developmental Neuroscience, 2004, 22, Jurič DM, Čarman-Kržan M. Interleukin-1[beta], but not IL-1[alpha], mediates nerve growth factor secretionfrom rat astrocytes via type I IL-1 receptor. International Journal of Developmental Neuroscience, 2001, 19, Pregledni znanstveni članek/review article 1. Jurič DM, Kržan M, Lipnik-Štangelj M. Histamine and astrocyte function. Pharmacological Research, članek, sprejet v tisk Žiberna L, Jurič DM. Histaminski receptor tipa 3 - od gena do terapevtske tarče Medicinski razgledi, 2013, 52, Mentor pri doktorskih disertacijah/supervisor for Doctoral Dissertations 1. Mele Tina. Vpliv monoaminskih živčnih prenašalcev na sintezo nevrotrofina-3 v celičnih kulturah astrocitov novorojenih podgan, = Regulatory role of monoamine neurotransmitters on neurotrophin-3 synthesis in neonatal rat astrocytes in culture: doktorska disertacija. Ljubljana: [T. Mele], XV, 119 f., [7] f. pril., ilustr. [COBISS.SI-ID ] Somentor pri magistrskih delih (bolonjski študij)/co-supervisor for Master's Theses (Bologna study programme) 1. Levstik Jure. Vpliv kisika na nevrotrofično aktivnost astrocitov po zastrupitvi z ogljikovim monoksidom= The influence of oxygen on neurotrophic activity of astrocytes after carbon monoxide intoxication, enovitni magistrski študij farmacije. Ljubljana: [J. Levstik], VII, 57 f., tabele. [COBISS.SI-ID ] Somentor drugo/co-supervisor - Other 1. Loboda Črt, Mlakar Manja. Optimizacija zdravljenja s kisikom pri zastrupitvah z ogljikovim monoksidom. Ljubljana: [Č. Loboda, M. Mlakar], f., [2] str. pril., graf. prikazi. [COBISS.SI-ID ] Nagrada: Fakultetna Prešernova nagrada za leto